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CS-W001157 4
Total: USD 88.00

H-D-Glu(OBzl)-OH

  • CAS No. 2578-33-8

  • Cat. No. CS-W012854
  • Purity≥97%
  • MDL No.MFCD00063111

*For research and further manufacturing use only, not for direct human use.

H-D-Glu(OBzl)-OH|CS-W012854

Structure of 2578-33-8

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General Information

  • CAS No. 2578-33-8
  • Cat. No. CS-W012854
  • Purity ≥97%
  • MDL No. MFCD00063111
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₅NO₄
  • Molecular Weight 237.26
  • Synonym(s) None
  • SMILES N[C@H](CCC(OCC1=CC=CC=C1)=O)C(O)=O

Description

H-D-Glu(OBzl)-OH is a protected aspartic acid derivative featuring a benzyl ester group at the C-terminal carboxylate, enabling stable incorporation into peptide chains. This configuration supports efficient coupling under standard conditions and facilitates selective deprotection during synthetic workflows.

Application

H-D-Glu(OBzl)-OH serves as a key chiral building block for the synthesis of peptide-based pharmaceuticals and bioactive molecules. The benzyl-protected glutamic acid moiety enables orthogonal functional group manipulation, facilitates efficient purification, and supports robust coupling reactions in solid-phase and solution-phase peptide synthesis. Its bench-stable nature and compatibility with standard amino acid coupling protocols make it a reliable choice for constructing complex peptide scaffolds.

Synthesis

  • Route1

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 10, # 12 p. 1361 - 1363
  • Route2

    References

    • Tetrahedron, , vol. 2, p. 211,226 Acta Chimica Academiae Scientiarum Hungaricae, , vol. 6, p. 219,226

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   89.62
  • LogP   0.9219
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   6

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