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CS-W001157 4
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Thiazole-5-carbonitrile

  • CAS No. 25742-12-5

  • Cat. No. CS-W006024
  • Purity≥98%
  • MDL No.MFCD06797206
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Thiazole-5-carbonitrile|CS-W006024

Structure of 25742-12-5

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Description

Thiazole-5-carbonitrile serves as a pivotal heterocyclic scaffold in medicinal chemistry, featuring a nitrile group at the 5-position that enhances metabolic stability and facilitates downstream functionalization. This electron-deficient thiazole integrates readily into bioactive molecules, offering robust reactivity under standard conditions for coupling and derivatization workflows.

Application

Thiazole-5-carbonitrile serves as a versatile building block in medicinal chemistry and materials science, enabling efficient access to functionalized heterocycles via nucleophilic substitution and transition-metal-catalyzed coupling reactions. Its nitrile group offers high bench stability and compatibility with diverse reaction conditions, facilitating downstream derivatization. The molecule functions as a key scaffold component in bioactive compound synthesis and exhibits favorable solubility and purification characteristics for scalable applications.

General Information

  • CAS No. 25742-12-5
  • Cat. No. CS-W006024
  • Purity ≥98%
  • MDL No. MFCD06797206
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₂N₂S
  • Molecular Weight 110.14
  • Synonym(s) 5-Thiazolecarbonitrile
  • SMILES S1C(=CN=C1)C#N

Computational Chemistry Data

  • TPSA   36.68
  • LogP   1.01478
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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