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CS-W001157 4
Total: USD 88.00

m-PEG16-NHS ester

  • CAS No. 2563873-83-4

  • Cat. No. CS-0900853
  • Molecule weight861.97
  • Purity≥97%
  • MDL No.MFCD13184971

*For research and further manufacturing use only, not for direct human use.

m-PEG16-NHS ester|CS-0900853

Structure of 2563873-83-4

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General Information

  • CAS No. 2563873-83-4
  • Cat. No. CS-0900853
  • Purity ≥97%
  • MDL No. MFCD13184971
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃₈H₇₁NO₂₀
  • Molecular Weight 861.97
  • Synonym(s) None
  • SMILES O=C(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC)ON1C(CCC1=O)=O

Description

This polyether-functionalized dioxopyrrolidinyl ester features a 47-atom aliphatic chain terminated by a reactive ester group, enabling efficient coupling to carboxylic acid-containing biomolecules. The extended polyether backbone imparts high solubility in polar solvents and enhances stability under aqueous conditions, making it suitable for conjugation workflows requiring prolonged shelf life and minimal aggregation.

Application

2,5-Dioxopyrrolidin-1-yl 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47-hexadecaoxapentacontan-50-oate serves as a robust, bench-stable ester activating agent for carboxylic acids in peptide coupling and polymer functionalization. Its extended polyether chain enhances solubility in polar aprotic solvents while maintaining high reactivity under standard conditions. The N-hydroxypyrrolidone leaving group facilitates clean reaction progress with minimal racemization, enabling efficient formation of esters and amides across diverse substrates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319
Precautionary Statements : P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

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Computational Chemistry Data

  • TPSA   211.36
  • LogP   -0.1209
  • H_Acceptors   20
  • H_Donors   0
  • Rotatable_Bonds   49

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