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CS-W001157 4
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4-Iodotetrahydro-2H-pyran,97%,stabilized with Na2O3S2

  • CAS No. 25637-18-7

  • Cat. No. CS-W004278
  • Purity97%,stabilized with Na2O3S2
  • MDL No.MFCD06797467

*For research and further manufacturing use only, not for direct human use.

4-Iodotetrahydro-2H-pyran,97%,stabilized with Na2O3S2|CS-W004278

Structure of 25637-18-7

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General Information

  • CAS No. 25637-18-7
  • Cat. No. CS-W004278
  • Purity 97%,stabilized with Na2O3S2
  • MDL No. MFCD06797467
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₉IO
  • Molecular Weight 212.03
  • Synonym(s) 4-iodotetrahydropyran
  • SMILES IC1CCOCC1

Description

4-Iodotetrahydro-2H-pyran, 97%, stabilized with Na₂O₃S₂ delivers a moisture-tolerant, bench-stable iodide source for C–C bond formation. The tetrahydropyran ring provides conformational rigidity, while the iodine atom enables efficient cross-coupling reactions under standard conditions. This stabilized variant ensures consistent reactivity and shelf life.

Application

4-Iodotetrahydro-2H-pyran, 97%, stabilized with Na₂S₂O₃ serves as a versatile iodinated building block for transition-metal-catalyzed cross-coupling reactions. The tetrahydropyran scaffold provides excellent functional group tolerance and bench stability, enabling reliable incorporation into complex molecular architectures. Its reactivity facilitates efficient C–C and C–heteroatom bond formation under standard Suzuki, Stille, or Negishi conditions, making it a practical choice for synthetic medicinal chemistry and natural product synthesis workflows.

Synthesis

  • Route1

    References

    • Fernandez-Salas, Jose A.; Maestro, M. Carmen; Rodriguez-Fernandez, M. Mercedes; Garcia-Ruano, Jose L.; Alonso, Ines Organic Letters, 2013 , vol. 15, # 7 p. 1658 - 1661
  • Route2

    References

    • Journal of the Chemical Society, , p. 910,913
  • Route3

    References

    • Journal of the Chemical Society, , p. 910,913

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   9.23
  • LogP   1.6004
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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