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CS-W001157 4
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2,2'-Bis(dicyclohexylphosphino)biphenyl

  • CAS No. 255897-36-0

  • Cat. No. CS-0035221
  • Purity≥97%
  • MDL No.MFCD07368358

*For research and further manufacturing use only, not for direct human use.

2,2'-Bis(dicyclohexylphosphino)biphenyl|CS-0035221

Structure of 255897-36-0

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General Information

  • CAS No. 255897-36-0
  • Cat. No. CS-0035221
  • Purity ≥97%
  • MDL No. MFCD07368358
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃₆H₅₂P₂
  • Molecular Weight 546.75
  • Synonym(s) 2,2'-Bis(dicyclohexylphosphino)-1,1'-biphenyl
  • SMILES C1(C2=CC=CC=C2P(C3CCCCC3)C4CCCCC4)=C(P(C5CCCCC5)C6CCCCC6)C=CC=C1

Description

This diphosphine ligand features two sterically hindered dicyclohexylphosphino groups attached to a biphenyl backbone, enabling robust coordination to transition metals. Its electron-rich character enhances catalytic activity in cross-coupling reactions and stabilizes low-valent metal complexes under standard conditions.

Application

2,2'-Bis(dicyclohexylphosphino)biphenyl serves as a highly effective, bench-stable ligand in palladium-catalyzed cross-coupling reactions. Its bulky dicyclohexylphosphino groups provide strong electron donation and steric protection, enabling efficient coupling of challenging substrates such as aryl chlorides and heterocyclic halides. The ligand demonstrates broad functional group tolerance and facilitates catalyst turnover under mild conditions, making it ideal for complex molecule synthesis in medicinal chemistry and process development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   0
  • LogP   10.8988
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   7

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