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CS-W001157 4
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(4-Fluorophenyl)(piperidin-4-yl)methanone hydrochloride

  • CAS No. 25519-78-2

  • Cat. No. CS-W014644
  • Molecule weight243.71
  • Purity≥98%
  • MDL No.MFCD00044912

*For research and further manufacturing use only, not for direct human use.

(4-Fluorophenyl)(piperidin-4-yl)methanone hydrochloride|CS-W014644

Structure of 25519-78-2

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General Information

  • CAS No. 25519-78-2
  • Cat. No. CS-W014644
  • Purity ≥98%
  • MDL No. MFCD00044912
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₅ClFNO
  • Molecular Weight 243.71
  • Synonym(s) 4-FLUOROPHENYL 4-PIPERIDINYL METHANONE
  • SMILES FC1=CC=C(C(C2CCNCC2)=O)C=C1.Cl

Description

(4-Fluorophenyl)(piperidin-4-yl)methanone hydrochloride features a fluorinated aryl group paired with a piperidine-containing amide, delivering enhanced metabolic stability and improved membrane permeability. This scaffold integrates well into kinase inhibitor frameworks and serves as a key building block in medicinal chemistry for CNS-targeted compounds.

Application

(4-Fluorophenyl)(piperidin-4-yl)methanone hydrochloride serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles and pharmaceutical scaffolds. The molecule combines a fluorinated aryl group with a piperidine-containing amide, offering enhanced metabolic stability and favorable pharmacokinetic properties. Its crystalline hydrochloride salt form ensures excellent bench stability, ease of handling, and straightforward purification, facilitating integration into multi-step synthesis workflows.

Synthesis

  • Route1
    • 1-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethanone|CS-0647731
      25519-77-1
    • ~%
    • In-stock
      (4-Fluorophenyl)(piperidin-4-yl)methanone hydrochloride|CS-W014644
      25519-78-2

    References

    • US4046900 A1, ;
  • Route2
    • tert-Butyl 4-(4-fluorobenzoyl)piperidine-1-carboxylate|CS-W001458
      160296-40-2
    • ~%
    • In-stock
      (4-Fluorophenyl)(piperidin-4-yl)methanone hydrochloride|CS-W014644
      25519-78-2

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 20, # 1 p. 341 - 345

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.1
  • LogP   2.4298
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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