Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

4-(2-(Trifluoromethyl)phenyl)piperidine hydrochloride

  • CAS No. 255051-14-0

  • Cat. No. CS-W002894
  • Purity≥97%
  • MDL No.MFCD02178914

*For research and further manufacturing use only, not for direct human use.

4-(2-(Trifluoromethyl)phenyl)piperidine hydrochloride|CS-W002894

Structure of 255051-14-0

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 255051-14-0
  • Cat. No. CS-W002894
  • Purity ≥97%
  • MDL No. MFCD02178914
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₅ClF₃N
  • Molecular Weight None
  • Synonym(s) 2-trifluoromethylphenyl piperidine hydrochloride
  • SMILES FC(F)(F)C1=CC=CC=C1C2CCNCC2.Cl

Description

This piperidine derivative features a trifluoromethyl-substituted aryl group that enhances lipophilicity and metabolic stability. The hydrochloride salt form ensures improved solubility and handling under standard conditions, making it well-suited for medicinal chemistry applications requiring robust scaffold integration.

Application

4-(2-(Trifluoromethyl)phenyl)piperidine hydrochloride serves as a key building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles through standard coupling and functionalization protocols. Its trifluoromethyl aryl group enhances metabolic stability and membrane permeability, while the piperidine core provides a versatile scaffold for amine derivatization. The hydrochloride salt ensures improved crystallinity and handling stability, facilitating purification and scale-up in industrial R&D workflows.

Synthesis

  • Route1
    • null|null
      1370256-36-2
    • ~61%
    • In-stock
      4-(2-(Trifluoromethyl)phenyl)piperidine hydrochloride|CS-W002894
      255051-14-0

    References

    • Conway, Richard J.; Valant, Celine; Christopoulos, Arthur; Robertson, Alan D.; Capuano, Ben; Crosby, Ian T. Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 7 p. 2560 - 2564
  • Route2
    • null|null
      821768-10-9
    • ~%
    • In-stock
      4-(2-(Trifluoromethyl)phenyl)piperidine hydrochloride|CS-W002894
      255051-14-0

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 7 p. 2560 - 2564
  • Route3
    • null|null
      3612-20-2
    • ~%
    • In-stock
      4-(2-(Trifluoromethyl)phenyl)piperidine hydrochloride|CS-W002894
      255051-14-0

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 7 p. 2560 - 2564

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   12.03
  • LogP   3.5942
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 255051-14-0 sigma255051-14-0 manufacturer255051-14-0 price255051-14-0 structure255051-14-0 SDSbuy 255051-14-0255051-14-0 supplier255051-14-0 uses255051-14-0 molecular weightprice of 255051-14-0255051-14-0 chemical name formula of 255051-14-0
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label