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CS-W001157 4
Total: USD 88.00

1-Bromo-4-(methoxymethoxy)benzene

  • CAS No. 25458-45-1

  • Cat. No. CS-0197086
  • Purity≥98%
  • MDL No.None
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

1-Bromo-4-(methoxymethoxy)benzene|CS-0197086

Structure of 25458-45-1

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Description

1-Bromo-4-(methoxymethoxy)benzene features a bromine atom and a methoxymethoxy group positioned para to each other on the benzene ring. This configuration enables selective cross-coupling reactions under standard conditions, while the ether functionality enhances solubility in common organic solvents. The molecule exhibits bench-stable handling characteristics and integrates readily into complex synthetic sequences.

Application

1-Bromo-4-(methoxymethoxy)benzene serves as a versatile aryl halide building block for Suzuki and Stille coupling reactions, offering excellent functional group tolerance and bench stability. The methoxymethoxy group provides reliable protection of phenolic hydroxyls under standard conditions, enabling orthogonal deprotection strategies in complex molecule synthesis. Its compatibility with palladium-catalyzed transformations makes it a practical choice for constructing biaryl scaffolds in medicinal chemistry and materials science applications.

General Information

  • CAS No. 25458-45-1
  • Cat. No. CS-0197086
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉BrO₂
  • Molecular Weight 217.06
  • Synonym(s) p-methoxymethoxybromobenzene
  • SMILES COCOC1=CC=C(C=C1)Br

Computational Chemistry Data

  • TPSA   18.46
  • LogP   2.4318
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   3

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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