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CS-W001157 4
Total: USD 88.00

H-Asn-OtBu

  • CAS No. 25456-86-4

  • Cat. No. CS-W016790
  • Molecule weight188.22
  • Purity≥98%
  • MDL No.MFCD00190755

*For research and further manufacturing use only, not for direct human use.

H-Asn-OtBu|CS-W016790

Structure of 25456-86-4

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General Information

  • CAS No. 25456-86-4
  • Cat. No. CS-W016790
  • Purity ≥98%
  • MDL No. MFCD00190755
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₆N₂O₃
  • Molecular Weight 188.22
  • Synonym(s) tert-butyl L-asparaginate
  • SMILES N[C@@H](CC(N)=O)C(OC(C)(C)C)=O

Description

H-Asn-OtBu is a protected asparagine derivative featuring a labile tert-butyl ester group, enabling selective coupling in peptide synthesis. This residue integrates readily into C-terminal extensions and supports efficient deprotection under mild acidic conditions, offering high stability during storage and handling.

Application

H-Asn-OtBu serves as a robust, bench-stable building block for the synthesis of peptide-based pharmaceuticals and peptidomimetics. Its tert-butyl ester functionality provides excellent stability during storage and handling, while enabling straightforward deprotection under mild acidic conditions. The side chain amide group offers predictable reactivity in standard coupling protocols, facilitating efficient incorporation into diverse peptide sequences with high fidelity.

Synthesis

  • Route1

    References

    • Helvetica chimica acta, , vol. 54, # 1 p. 398 - 422

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   96.4
  • LogP   0.58077
  • H_Acceptors   4
  • H_Donors   3
  • Rotatable_Bonds   3

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