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CS-W001157 4
Total: USD 88.00

1-(4-Bromo-2-chlorophenyl)ethanone

  • CAS No. 252561-81-2

  • Cat. No. CS-W019153
  • Molecule weight233.49
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-(4-Bromo-2-chlorophenyl)ethanone|CS-W019153

Structure of 252561-81-2

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General Information

  • CAS No. 252561-81-2
  • Cat. No. CS-W019153
  • Purity ≥95%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆BrClO
  • Molecular Weight 233.49
  • Synonym(s) ethanone, 1-(4-bromo-2-chlorophenyl)-
  • SMILES CC(C1=CC=C(Br)C=C1Cl)=O

Description

1-(4-Bromo-2-chlorophenyl)ethanone features a brominated and chlorinated aromatic ring flanked by a ketone-functionalized ethyl side chain. This electron-deficient aryl ketone integrates readily into cross-coupling reactions and serves as a key intermediate in the synthesis of pharmaceuticals and agrochemicals. Its bench-stable nature enables reliable handling under standard conditions.

Application

1-(4-Bromo-2-chlorophenyl)ethanone serves as a versatile building block in medicinal chemistry and heterocyclic synthesis, enabling efficient construction of biaryl scaffolds and functionalized benzene derivatives. Its bromo and chloro substituents provide orthogonal sites for palladium-catalyzed cross-coupling reactions, while the acetyl group facilitates nucleophilic transformations. The compound exhibits excellent bench stability and is compatible with standard purification protocols, making it well-suited for iterative synthetic sequences in API development.

Synthesis

  • Route1
    • null|null
      625446-26-6
    • null|null
      75-16-1
    • ~82%
    • In-stock
      1-(4-Bromo-2-chlorophenyl)ethanone|CS-W019153
      252561-81-2

    References

    • WO2004/74270 A2, ; Page 64 ;
  • Route2
    • null|null
      875306-64-2
    • ~37%
    • In-stock
      1-(4-Bromo-2-chlorophenyl)ethanone|CS-W019153
      252561-81-2

    References

    • US2009/170920 A1, ; Page/Page column 13-14 ; US 20090170920 A1
  • Route3
    • null|null
      75-16-1
    • null|null
      875306-64-2
    • ~%
    • In-stock
      1-(4-Bromo-2-chlorophenyl)ethanone|CS-W019153
      252561-81-2

    References

    • WO2008/103277 A2, ; Page/Page column 190-191 ; WO 2008/103277 A2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   3.3051
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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