2-Bromo-5-iodobenzoic acid

Name: 2-Bromo-5-iodobenzoic acid
Brand: ChemScene
Availability: InStock
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CAS No. 25252-00-0
Cat. No. CS-D1730
Purity≥97%
MDL No.MFCD00079716

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 25252-00-0
Cat. No. CS-D1730
Purity ≥97%
MDL No. MFCD00079716
Storage RT, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₄BrIO₂
Molecular Weight 326.91
Synonym(s) 2-Bromine-5-Iodine Benzoic Acids
SMILES O=C(O)C1=CC(I)=CC=C1Br

Description

2-Bromo-5-iodobenzoic acid features a benzoic acid core substituted with bromine at the ortho position and iodine at the para position, enabling direct functionalization in cross-coupling reactions. The dual halogenation pattern supports sequential derivatization, while the carboxylic acid group facilitates conjugation or salt formation for improved solubility and handling under standard conditions.

Application

2-Bromo-5-iodobenzoic acid serves as a versatile building block for palladium-catalyzed cross-coupling reactions, enabling efficient construction of biaryl and heteroaryl scaffolds. The orthogonal halogenation pattern facilitates sequential functionalization, while the carboxylic acid group supports direct derivatization or incorporation into pharmaceutical intermediates. Bench-stable and readily purified by recrystallization, it functions reliably in standard synthetic workflows requiring precise regiocontrol.

Synthesis

Route1
- 124-38-9
- In-stock
  
  589-87-7
- ~64%
- In-stock
  
  25252-00-0
References
- Lulinski, Sergiusz; Serwatowski, Janusz; Szczerbinska, Magdalena European Journal of Organic Chemistry, 2008 , # 10 p. 1797 - 1801

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 37.3
LogP 2.7519
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Carboxylic Acid

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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2-Bromo-5-iodobenzoic acid

CAS No. 25252-00-0

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