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CS-W001157 4
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4-Methylpyridazine-3-carboxylic acid

  • CAS No. 25247-28-3

  • Cat. No. CS-0050803
  • Molecule weightNone
  • Purity≥96%
  • MDL No.MFCD09834367

*For research and further manufacturing use only, not for direct human use.

4-Methylpyridazine-3-carboxylic acid|CS-0050803

Structure of 25247-28-3

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General Information

  • CAS No. 25247-28-3
  • Cat. No. CS-0050803
  • Purity ≥96%
  • MDL No. MFCD09834367
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆N₂O₂
  • Molecular Weight None
  • Synonym(s) 4-Methylpyridazine-3-carboxylicacid
  • SMILES CC1=C(N=NC=C1)C(O)=O

Description

4-Methylpyridazine-3-carboxylic acid features a conjugated pyridazine core bearing a methyl group at the 4-position and a carboxylic acid at the 3-position, delivering enhanced solubility and stability under standard conditions. This scaffold integrates readily into bioactive molecule design, particularly in kinase inhibitor and pharmaceutical lead development, where its electron-deficient heterocycle supports targeted interactions.

Application

4-Methylpyridazine-3-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of heterocyclic scaffolds through standard coupling and functional group transformation protocols. Its dual functionality—electron-deficient pyridazine core and carboxylic acid group—facilitates conjugation via amide bond formation and supports metal-catalyzed cross-coupling reactions. The methyl substituent enhances metabolic stability and modulates electronic properties, while the compound exhibits good bench stability and ease of purification, making it well-suited for high-throughput library synthesis and process-scale applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   63.08
  • LogP   0.48322
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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