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CS-W001157 4
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9-Methyl-β-carboline

  • CAS No. 2521-07-5

  • Cat. No. CS-0102858
  • Molecule weight182.22
  • Purity≥97%
  • MDL No.MFCD18803860

*For research and further manufacturing use only, not for direct human use.

9-Methyl-β-carboline|CS-0102858

Structure of 2521-07-5

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General Information

  • CAS No. 2521-07-5
  • Cat. No. CS-0102858
  • Purity ≥97%
  • MDL No. MFCD18803860
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₀N₂
  • Molecular Weight 182.22
  • Synonym(s) None
  • SMILES CN1C2=C(C=CC=C2)C3=C1C=NC=C3

Description

9-Methyl-β-carboline delivers a rigid, electron-rich heterocyclic scaffold with enhanced metabolic stability. This fused tricyclic structure features a methyl group at the 9-position, which modulates electronic properties and improves solubility in organic solvents. It serves as a key building block in medicinal chemistry for developing bioactive compounds targeting neurological and oncological pathways.

Application

9-Methyl-β-carboline serves as a privileged heterocyclic scaffold in medicinal chemistry, enabling rapid access to bioactive molecules through well-established functionalization at the C-1 and C-3 positions. Its inherent stability and compatibility with common coupling reactions facilitate efficient synthesis of analogs for target-directed drug discovery. The compound functions as a versatile building block in the construction of alkaloid-based pharmacophores and exhibits favorable handling properties for routine bench-scale applications.

Synthesis

  • Route1
    • In-stock
      Norharmane|CS-W008566
      244-63-3
    • null|null
      74-88-4
    • ~75%
    • In-stock
      9-Methyl-β-carboline|CS-0102858
      2521-07-5

    References

    • Cao, Rihui; Chen, Qi; Hou, Xuerui; Chen, Hongsheng; Guan, Huaji; Ma, Yan; Peng, Wenlie; Xu, Anlong Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 17 p. 4613 - 4623
  • Route2
    • null|null
      372954-67-1
    • ~%
    • In-stock
      9-Methyl-β-carboline|CS-0102858
      2521-07-5

    References

    • Zhang, Haiming; Larock, Richard C. Journal of Organic Chemistry, 2002 , vol. 67, # 20 p. 7048 - 7056
  • Route3

    References

    • Zhang, Guoxian; Cao, Rihui; Guo, Liang; Ma, Qin; Fan, Wenxi; Chen, Xuemei; Li, Jianru; Shao, Guang; Qiu, Liqin; Ren, Zhenghua European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 21 - 31

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

Quality Control

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Computational Chemistry Data

  • TPSA   17.82
  • LogP   2.7265
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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