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CS-W001157 4
Total: USD 88.00

4-Chloro-2,6-difluorobenzaldehyde

  • CAS No. 252004-45-8

  • Cat. No. CS-0157707
  • Purity≥97%
  • MDL No.MFCD03094460

*For research and further manufacturing use only, not for direct human use.

4-Chloro-2,6-difluorobenzaldehyde|CS-0157707

Structure of 252004-45-8

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General Information

  • CAS No. 252004-45-8
  • Cat. No. CS-0157707
  • Purity ≥97%
  • MDL No. MFCD03094460
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₃ClF₂O
  • Molecular Weight 176.55
  • Synonym(s) None
  • SMILES C1=C(C=C(C(=C1F)C=O)F)Cl

Description

4-Chloro-2,6-difluorobenzaldehyde features a trifluorinated aromatic core with orthogonal electron-withdrawing substituents, enabling precise tuning of reactivity in cross-coupling and electrophilic substitution processes. The aldehyde functionality provides a handle for rapid derivatization, while the fluorine atoms enhance metabolic stability and modulate electronic properties. This compound exhibits excellent bench stability and compatibility with diverse reaction conditions.

Application

4-Chloro-2,6-difluorobenzaldehyde serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient construction of heterocyclic scaffolds via nucleophilic addition and condensation reactions. Its electron-deficient aromatic ring enhances reactivity in coupling processes, while the aldehyde functionality offers direct access to imines, hydrazones, and amides. Bench-stable and compatible with standard purification methods, it facilitates scalable synthesis workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.4307
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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