(R)-2-Chloro-2-fluoroacetic acid

Name: (R)-2-Chloro-2-fluoroacetic acid
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 25197-76-6
Cat. No. CS-0434926
Purity≥95%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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(R)-2-Chloro-2-fluoroacetic acid|CS-0434926

Structure of 25197-76-6

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Description

(R)-2-Chloro-2-fluoroacetic acid is a chiral alpha-halo carboxylic acid featuring adjacent chlorine and fluorine substituents on the alpha carbon. This configuration imparts enhanced electrophilicity and metabolic stability, enabling selective derivatization in peptide synthesis and chemical biology applications. The stereochemical purity supports reproducible reactivity in asymmetric transformations.

Application

(R)-2-Chloro-2-fluoroacetic acid serves as a valuable chiral building block in medicinal chemistry, enabling the synthesis of fluorinated α-amino acids and bioactive heterocycles. Its high functional group tolerance and bench stability facilitate straightforward derivatization via nucleophilic substitution or condensation reactions. The molecule's defined stereochemistry supports enantioselective synthesis workflows, making it a practical choice for constructing complex pharmaceutical scaffolds with controlled stereochemical integrity.

General Information

CAS No. 25197-76-6
Cat. No. CS-0434926
Purity ≥95%
MDL No. None
Storage 4°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂H₂ClFO₂
Molecular Weight 112.49
Synonym(s) None
SMILES OC([C@H](F)Cl)=O

Computational Chemistry Data

TPSA 37.3
LogP 0.6054
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Fatty chain compounds

Key Words

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(R)-2-Chloro-2-fluoroacetic acid

CAS No. 25197-76-6

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