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CS-W001157 4
Total: USD 88.00

N-(tert-Butyl)benzenesulfonamide

  • CAS No. 2512-24-5

  • Cat. No. CS-0038128
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

N-(tert-Butyl)benzenesulfonamide|CS-0038128

Structure of 2512-24-5

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General Information

  • CAS No. 2512-24-5
  • Cat. No. CS-0038128
  • Purity ≥96%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₅NO₂S
  • Molecular Weight 213.30
  • Synonym(s) N-tert-butylbenzenesulfonamide
  • SMILES CC(C)(C)NS(=O)(=O)C1=CC=CC=C1

Description

N-(tert-Butyl)benzenesulfonamide is a bench-stable sulfonamide featuring a sterically hindered tert-butyl group that enhances resistance to nucleophilic attack. This substitution pattern improves metabolic stability and solubility in organic media, making it a robust scaffold for medicinal chemistry. The para-substituted benzene ring provides a rigid platform for molecular integration.

Application

N-(tert-Butyl)benzenesulfonamide serves as a stable, bench-ready sulfonamide building block for medicinal chemistry and synthetic applications. Its tert-butyl group enhances steric protection and improves solubility, facilitating purification and handling. It functions effectively in nucleophilic displacement reactions, enabling the construction of diverse sulfonamide-containing scaffolds relevant to pharmaceutical development. The compound exhibits excellent functional group tolerance and compatibility with standard coupling protocols.

Synthesis

  • Route1
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    • ~99%
    • In-stock
      N-(tert-Butyl)benzenesulfonamide|CS-0038128
      2512-24-5

    References

    • Kiefer, Lionel; Gorojankina, Tatiana; Dauban, Philippe; Faure, Helene; Ruat, Martial; Dodd, Robert H. Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 24 p. 7483 - 7487
  • Route2
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      108-98-5
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      75-64-9
    • ~88%
    • In-stock
      N-(tert-Butyl)benzenesulfonamide|CS-0038128
      2512-24-5

    References

    • Taniguchi, Nobukazu European Journal of Organic Chemistry, 2010 , # 14 p. 2670 - 2673
  • Route3
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      108-98-5
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      75-64-9
    • ~%
    • In-stock
      N-(tert-Butyl)-S-phenylthiohydroxylamine|CS-0154866
      19117-31-8
    • In-stock
      N-(tert-Butyl)benzenesulfonamide|CS-0038128
      2512-24-5
    • null|null
      94600-72-3

    References

    • European Journal of Organic Chemistry, , # 14 p. 2670 - 2673

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.17
  • LogP   1.7634
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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