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CS-W001157 4
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2-(4-Methylpiperazin-1-yl)phenylboronic acid

  • CAS No. 250383-80-3

  • Cat. No. CS-0044983
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-(4-Methylpiperazin-1-yl)phenylboronic acid|CS-0044983

Structure of 250383-80-3

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General Information

  • CAS No. 250383-80-3
  • Cat. No. CS-0044983
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₇BN₂O₂
  • Molecular Weight 220.08
  • Synonym(s) [2-(4-methyl-1-piperazinyl)phenyl]boronic acid
  • SMILES CN1CCN(C2=CC=CC=C2B(O)O)CC1

Description

This boronate moiety integrates a 4-methylpiperazine ring with a phenylboronic acid scaffold, enabling efficient Suzuki-Miyaura cross-coupling under standard conditions. The electron-rich piperazine group enhances reactivity while maintaining bench-stable handling properties, making it ideal for constructing complex biaryl architectures in medicinal chemistry and materials synthesis.

Application

2-(4-Methylpiperazin-1-yl)phenylboronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl scaffolds under mild conditions. The piperazine moiety provides enhanced solubility and metabolic stability, while the boronic acid functionality offers excellent bench stability and compatibility with diverse functional groups. This compound facilitates rapid access to complex heterocyclic architectures relevant to medicinal chemistry and materials science.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   46.94
  • LogP   -0.8818
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   2

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