Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

8-Chloro-2-methoxy-1,5-naphthyridine

  • CAS No. 249889-68-7

  • Cat. No. CS-W006802
  • Molecule weight194.62
  • Purity≥98%
  • MDL No.MFCD09027618

*For research and further manufacturing use only, not for direct human use.

8-Chloro-2-methoxy-1,5-naphthyridine|CS-W006802

Structure of 249889-68-7

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 249889-68-7
  • Cat. No. CS-W006802
  • Purity ≥98%
  • MDL No. MFCD09027618
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₇ClN₂O
  • Molecular Weight 194.62
  • Synonym(s) 8-Chloro-2-methoxy-1,5phthyridine
  • SMILES COC1=NC2=C(Cl)C=CN=C2C=C1

Description

8-Chloro-2-methoxy-1,5-naphthyridine is a heterocyclic building block featuring a chlorine atom at the 8-position and a methoxy group at the 2-position on the naphthyridine core. This substitution pattern enhances electron deficiency and directs regioselective functionalization in cross-coupling reactions. The compound exhibits bench-stable handling characteristics and compatibility with palladium-catalyzed transformations, enabling efficient access to advanced pharmaceutical intermediates and materials.

Application

8-Chloro-2-methoxy-1,5-naphthyridine serves as a versatile building block in medicinal chemistry, enabling efficient late-stage functionalization via palladium-catalyzed cross-coupling reactions. The chloro group at the 8-position provides high reactivity in Suzuki, Negishi, and Buchwald-Hartwig transformations, while the methoxy substituent at C2 enhances solubility and modulates electronic properties. Its stability under standard reaction conditions and compatibility with diverse functional groups make it well-suited for constructing complex heterocyclic scaffolds in API development.

Synthesis

  • Route1

    References

    • WO2008/124083 A2, ; Page/Page column 50 ; WO 2008/124083 A2
  • Route2
    • 4-Hydroxy-6-methoxy-1,5-naphthyridine-3-carboxylic acid|CS-0137841
      53241-85-3
    • ~%
    • In-stock
      8-Chloro-2-methoxy-1,5-naphthyridine|CS-W006802
      249889-68-7

    References

    • US2003/212084 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   35.01
  • LogP   2.2918
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 8-Chloro-2-methoxy-1,5-naphthyridine sigma8-Chloro-2-methoxy-1,5-naphthyridine manufacturer8-Chloro-2-methoxy-1,5-naphthyridine price8-Chloro-2-methoxy-1,5-naphthyridine structure8-Chloro-2-methoxy-1,5-naphthyridine SDSbuy 8-Chloro-2-methoxy-1,5-naphthyridine8-Chloro-2-methoxy-1,5-naphthyridine supplier8-Chloro-2-methoxy-1,5-naphthyridine uses8-Chloro-2-methoxy-1,5-naphthyridine molecular weightprice of 8-Chloro-2-methoxy-1,5-naphthyridine8-Chloro-2-methoxy-1,5-naphthyridine chemical name formula of 8-Chloro-2-methoxy-1,5-naphthyridine
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label