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CS-W001157 4
Total: USD 88.00

8-Chloro-2-methoxy-1,5-naphthyridine

  • CAS No. 249889-68-7

  • Cat. No. CS-W006802
  • Purity≥98%
  • MDL No.MFCD09027618
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

8-Chloro-2-methoxy-1,5-naphthyridine|CS-W006802

Structure of 249889-68-7

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Description

8-Chloro-2-methoxy-1,5-naphthyridine is a heterocyclic building block featuring a chlorine atom at the 8-position and a methoxy group at the 2-position on the naphthyridine core. This substitution pattern enhances electron deficiency and directs regioselective functionalization in cross-coupling reactions. The compound exhibits bench-stable handling characteristics and compatibility with palladium-catalyzed transformations, enabling efficient access to advanced pharmaceutical intermediates and materials.

Application

8-Chloro-2-methoxy-1,5-naphthyridine serves as a versatile building block in medicinal chemistry, enabling efficient late-stage functionalization via palladium-catalyzed cross-coupling reactions. The chloro group at the 8-position provides high reactivity in Suzuki, Negishi, and Buchwald-Hartwig transformations, while the methoxy substituent at C2 enhances solubility and modulates electronic properties. Its stability under standard reaction conditions and compatibility with diverse functional groups make it well-suited for constructing complex heterocyclic scaffolds in API development.

General Information

  • CAS No. 249889-68-7
  • Cat. No. CS-W006802
  • Purity ≥98%
  • MDL No. MFCD09027618
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₇ClN₂O
  • Molecular Weight 194.62
  • Synonym(s) 8-Chloro-2-methoxy-1,5phthyridine
  • SMILES COC1=NC2=C(Cl)C=CN=C2C=C1

Computational Chemistry Data

  • TPSA   35.01
  • LogP   2.2918
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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