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Structure of 249889-68-7
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8-Chloro-2-methoxy-1,5-naphthyridine is a heterocyclic building block featuring a chlorine atom at the 8-position and a methoxy group at the 2-position on the naphthyridine core. This substitution pattern enhances electron deficiency and directs regioselective functionalization in cross-coupling reactions. The compound exhibits bench-stable handling characteristics and compatibility with palladium-catalyzed transformations, enabling efficient access to advanced pharmaceutical intermediates and materials.
8-Chloro-2-methoxy-1,5-naphthyridine serves as a versatile building block in medicinal chemistry, enabling efficient late-stage functionalization via palladium-catalyzed cross-coupling reactions. The chloro group at the 8-position provides high reactivity in Suzuki, Negishi, and Buchwald-Hartwig transformations, while the methoxy substituent at C2 enhances solubility and modulates electronic properties. Its stability under standard reaction conditions and compatibility with diverse functional groups make it well-suited for constructing complex heterocyclic scaffolds in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: