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Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

Boc-His-OMe

  • CAS No. 2488-14-4

  • Cat. No. CS-0044702
  • Purity≥97%
  • MDL No.MFCD00167635

*For research and further manufacturing use only, not for direct human use.

Boc-His-OMe|CS-0044702

Structure of 2488-14-4

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General Information

  • CAS No. 2488-14-4
  • Cat. No. CS-0044702
  • Purity ≥97%
  • MDL No. MFCD00167635
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₉N₃O₄
  • Molecular Weight 269.30
  • Synonym(s) None
  • SMILES O=C([C@@H](NC(OC(C)(C)C)=O)CC1=CNC=N1)OC

Description

Boc-His-OMe features a protected imidazole side chain and methyl ester functionality, enabling stable incorporation into peptide sequences. This derivative simplifies purification and handling during solid-phase synthesis while maintaining compatibility with standard deprotection protocols.

Application

Boc-His-OMe serves as a protected histidine building block for peptide synthesis, enabling selective side-chain functionalization and N-terminal capping. The Boc group provides stable protection under acidic conditions, while the methyl ester facilitates subsequent hydrolysis or derivatization. This derivative exhibits excellent bench stability, compatibility with standard coupling protocols, and clean deprotection profiles, making it ideal for iterative solid-phase and solution-phase peptide assembly.

Synthesis

  • Route1
    • null|null
      196607-93-9
    • ~90%
    • In-stock
      Boc-His-OMe|CS-0044702
      2488-14-4

    References

    • Malanda Kimbonguila; Boucida; Guibe; Loffet Tetrahedron, 1997 , vol. 53, # 37 p. 12525 - 12538
  • Route2

    References

    • Sharma; Janardhan Reddy; Sree Lakshmi; Radha Krishna, Palakodety Tetrahedron Letters, 2004 , vol. 45, # 37 p. 6963 - 6965
  • Route3
    • null|null
      196607-97-3
    • ~74%
    • In-stock
      Boc-His-OMe|CS-0044702
      2488-14-4

    References

    • Malanda Kimbonguila; Boucida; Guibe; Loffet Tetrahedron, 1997 , vol. 53, # 37 p. 12525 - 12538

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   93.31
  • LogP   1.0185
  • H_Acceptors   5
  • H_Donors   2
  • Rotatable_Bonds   4

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