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CS-W001157 4
Total: USD 88.00

2-Thioxo-2,3-dihydro-1H-purin-6(9H)-one

  • CAS No. 2487-40-3

  • Cat. No. CS-0063941
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Thioxo-2,3-dihydro-1H-purin-6(9H)-one|CS-0063941

Structure of 2487-40-3

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General Information

  • CAS No. 2487-40-3
  • Cat. No. CS-0063941
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄N₄OS
  • Molecular Weight 168.18
  • Synonym(s) 6-Hydroxy-2-mercaptopurine
  • SMILES O=C1NC(NC2=C1N=CN2)=S

Description

Fmoc-N-amido-PEG9-acid is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Synthesis

  • Route1
    • 5,6-Diamino-2-thioxo-2,3-dihydropyrimidin-4(1H)-one, 85%|CS-1331813
      1004-76-8
    • ~%
    • In-stock
      2-Thioxo-2,3-dihydro-1H-purin-6(9H)-one|CS-0063941
      2487-40-3

    References

    • Journal of the American Chemical Society, , vol. 78, p. 217,219
  • Route2
    • null|null
      117043-67-1
    • ~%
    • In-stock
      2-Thioxo-2,3-dihydro-1H-purin-6(9H)-one|CS-0063941
      2487-40-3

    References

    • Journal of the American Chemical Society, , vol. 78, p. 217,219
  • Route3
    • 5,6-Diamino-2-thioxo-2,3-dihydropyrimidin-4(1H)-one, 85%|CS-1331813
      1004-76-8
    • null|null
      77287-34-4
    • ~%
    • In-stock
      2-Thioxo-2,3-dihydro-1H-purin-6(9H)-one|CS-0063941
      2487-40-3

    References

    • Journal of the American Chemical Society, , vol. 76, p. 5633,5635,5636 Journal of the American Chemical Society, , vol. 75, p. 263,264

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   77.33
  • LogP   0.30879
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   0

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