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CS-W001157 4
Total: USD 88.00

4-Amino-3-methoxybenzoic acid

  • CAS No. 2486-69-3

  • Cat. No. CS-M0329
  • Purity≥97%
  • MDL No.MFCD00016539

*For research and further manufacturing use only, not for direct human use.

4-Amino-3-methoxybenzoic acid|CS-M0329

Structure of 2486-69-3

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General Information

  • CAS No. 2486-69-3
  • Cat. No. CS-M0329
  • Purity ≥97%
  • MDL No. MFCD00016539
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉NO₃
  • Molecular Weight 167.16
  • Synonym(s) None
  • SMILES O=C(O)C(C=C1OC)=CC=C1N

Description

Key building block for the efficient synthesis of carbazole alkaloids mukonine and mukonidine via oxidative annulation.

Application

4-Amino-3-methoxybenzoic acid serves as a versatile building block in medicinal chemistry, enabling direct access to substituted benzimidazoles and other heterocyclic scaffolds via standard coupling and cyclization protocols. Its ortho-amino and methoxy groups provide complementary reactivity for sequential functionalization, while the carboxylic acid facilitates amide bond formation under common peptide coupling conditions. The compound exhibits good bench stability and is readily purified by recrystallization or column chromatography, supporting its use in scalable synthetic routes.

Synthesis

  • Route1

    References

    • US2012/107886 A1, ; Page/Page column 19 ;
  • Route2

    References

    • Journal of the Chemical Society, , vol. 119, p. 1431
  • Route3

    References

    • Journal of the Chemical Society, , vol. 111, p. 232

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   72.55
  • LogP   0.9756
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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