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CS-W001157 4
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N-Fmoc-N-methoxy-3-aminopropionic acid

  • CAS No. 247021-90-5

  • Cat. No. CS-W009291
  • Molecule weight341.36
  • Purity≥97%
  • MDL No.MFCD01861163

*For research and further manufacturing use only, not for direct human use.

N-Fmoc-N-methoxy-3-aminopropionic acid|CS-W009291

Structure of 247021-90-5

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General Information

  • CAS No. 247021-90-5
  • Cat. No. CS-W009291
  • Purity ≥97%
  • MDL No. MFCD01861163
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₉H₁₉NO₅
  • Molecular Weight 341.36
  • Synonym(s) None
  • SMILES O=C(O)CCN(C(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)OC

Description

N-Fmoc-N-methoxy-3-aminopropionic acid features a protected amine and a methoxy-functionalized side chain, enabling direct incorporation into peptide backbones without additional derivatization. The Fmoc group ensures efficient removal under mild basic conditions, while the methoxy moiety enhances solubility and stability during synthesis. This reagent streamlines access to functionalized amino acid building blocks for medicinal chemistry and peptide library development.

Application

N-Fmoc-N-methoxy-3-aminopropionic acid serves as a versatile building block for peptide synthesis and heterocycle construction, enabling efficient incorporation of functionalized amino acid surrogates. The Fmoc group provides orthogonal protection for primary amines, while the methoxy carbamate facilitates controlled release under mild acidic conditions. This compound exhibits excellent bench stability, simplifies purification by chromatography, and tolerates diverse reaction conditions—making it ideal for iterative synthetic workflows in medicinal chemistry and macrocycle development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   76.07
  • LogP   3.2736
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   6

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