4-Chloro-2,6-dimethylaniline Impurity

Name: 4-Chloro-2,6-dimethylaniline Impurity
Brand: ChemScene
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CAS No. 24596-18-7
Cat. No. CS-0013262
Purity≥98%
MDL No.MFCD01076576

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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4-Chloro-2,6-dimethylaniline Impurity|CS-0013262

Structure of 24596-18-7

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General Information

CAS No. 24596-18-7
Cat. No. CS-0013262
Purity ≥98%
MDL No. MFCD01076576
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₁₀ClN
Molecular Weight 155.62
Synonym(s) (4-Chloro-2,6-dimethylphenyl)amine; 2,6-Dimethyl-4-chloroaniline; 3,5-Dimethyl-4-aminochlorobenzene; 4-Chloro-2,6-xylidine, 2-Amino-5-chloro-m-xylene
SMILES ClC1=CC(C)=C(N)C(C)=C1

Description

4-Chloro-2,6-dimethylaniline serves as a key impurity in the synthesis of certain pharmaceutical intermediates. This electron-rich aromatic amine features ortho-methyl groups that confer steric protection and enhance stability under standard bench conditions. Its structure facilitates identification and monitoring in process development workflows through distinct chromatographic behavior.

Application

4-Chloro-2,6-dimethylaniline serves as a well-characterized impurity intermediate in the synthesis of pharmaceuticals requiring substituted aniline scaffolds. Its ortho-methyl groups confer enhanced bench stability and facilitate purification via crystallization or column chromatography. The chloro substituent enables subsequent coupling reactions (e.g., Suzuki-Miyaura, Ullmann) for constructing biaryl motifs, while the amine remains compatible with standard protecting group strategies. This compound functions as a reliable building block in process chemistry workflows targeting complex heterocyclic systems.

Synthesis

Route1
- 936628-10-3
- ~97%
- In-stock
  
  24596-18-7
References
- Corbo, Filomena; Franchini, Carlo; Lentini, Giovanni; Muraglia, Marilena; Ghelardini, Carla; Matucci, Rosanna; Galeotti, Nicoletta; Vivoli, Elisa; Tortorella, Vincenzo Journal of Medicinal Chemistry, 2007 , vol. 50, # 8 p. 1907 - 1915
Route2
- 872415-94-6
- ~%
- In-stock
  
  24596-18-7
References
- Journal of Medicinal Chemistry, , vol. 50, # 8 p. 1907 - 1915
Route3
- In-stock
  
  24596-19-8
- ~%
- In-stock
  
  24596-18-7
References
- Journal of Medicinal Chemistry, , vol. 50, # 8 p. 1907 - 1915

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS06
Signal Word : Danger	UN#: 2811
Class : 6.1	Packing Group : Ⅲ
Hazard Statements : H301-H315-H319-H335
Precautionary Statements : P261-P280-P405-P501

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Computational Chemistry Data

TPSA 26.02
LogP 2.53904
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Chloride

Analytical Science Drug Impurity Reference Substance Other Drugs Other impurity

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

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4-Chloro-2,6-dimethylaniline Impurity

CAS No. 24596-18-7

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