7-Chloro-8-fluoropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione

Name: 7-Chloro-8-fluoropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 2454397-75-0
Cat. No. CS-0148198
Molecule weight215.57
Purity≥97%
MDL No.None

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

7-Chloro-8-fluoropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione|CS-0148198

Structure of 2454397-75-0

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 2454397-75-0
Cat. No. CS-0148198
Purity ≥97%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₃ClFN₃O₂
Molecular Weight 215.57
Synonym(s) 7-chloro-8-fluoropyrido[4.3-d]pyrimidine-2,4(1Ht3H)-dione
SMILES O=C1NC2=C(C=NC(Cl)=C2F)C(N1)=O

Description

7-Chloro-8-fluoropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione features a fused bicyclic core with orthogonal electron-withdrawing halogens at C7 and C8, enhancing electrophilicity for directed functionalization. This bench-stable scaffold integrates readily into kinase inhibitor scaffolds and serves as a key building block in medicinal chemistry campaigns targeting ATP-binding sites.

Application

7-Chloro-8-fluoropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to pyrido[4,3-d]pyrimidine-based scaffolds. Its orthogonal reactivity profile—facilitated by the strategically positioned chloro and fluoro substituents—supports selective functionalization at C7 and C8, while the diketone core enables facile derivatization via condensation or nucleophilic substitution. The compound exhibits robust bench stability and compatibility with standard synthetic workflows, making it well-suited for modular library synthesis and process-scale applications.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 78.61
LogP 0.4039
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

2454397-75-0 sigma2454397-75-0 manufacturer2454397-75-0 price2454397-75-0 structure2454397-75-0 SDSbuy 2454397-75-02454397-75-0 supplier2454397-75-0 uses2454397-75-0 molecular weightprice of 2454397-75-02454397-75-0 chemical name formula of 2454397-75-0

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

7-Chloro-8-fluoropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione

CAS No. 2454397-75-0

Recommended Products