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Structure of 2454397-74-9
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Ethyl 4-amino-6-chloro-5-fluoronicotinate features a fluorinated pyridine core with complementary electron-withdrawing chlorine and amino substituents, enabling selective coupling reactions in medicinal chemistry. The ester handle facilitates downstream derivatization, while the para-fluoro and ortho-chloro groups enhance reactivity and metabolic stability in bioactive molecule synthesis.
Ethyl 4-amino-6-chloro-5-fluoronicotinate serves as a versatile building block in the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its electron-deficient pyridine core, combined with orthogonal functional groups—namely the amino, chloro, fluoro, and ester moieties—enables selective transformations under standard coupling and substitution conditions. The compound exhibits bench stability, facilitates efficient purification, and functions reliably in multi-step syntheses targeting kinase inhibitors and other medicinal chemistry scaffolds.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P280-P302+P352
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Lot numbers can be found on the outside label of a product: