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CS-W001157 4
Total: USD 88.00

1,3-Dioxan-2-one

  • CAS No. 2453-03-4

  • Cat. No. CS-0155207
  • Molecule weight102.09
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1,3-Dioxan-2-one|CS-0155207

Structure of 2453-03-4

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General Information

  • CAS No. 2453-03-4
  • Cat. No. CS-0155207
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₆O₃
  • Molecular Weight 102.09
  • Synonym(s) Trimethylene Carbonate
  • SMILES C1COC(=O)OC1

Description

1,3-Dioxan-2-one serves as a valuable cyclic carbonate intermediate in synthetic chemistry. This bench-stable, moisture-tolerant compound features a strained five-membered ring that readily undergoes nucleophilic ring-opening reactions. The carbonyl group at the 2-position enhances reactivity toward amines and alcohols, enabling efficient incorporation into functional polymers and bioconjugation workflows.

Application

1,3-Dioxan-2-one serves as a versatile building block in synthetic organic chemistry, enabling efficient access to cyclic carbonate derivatives and functionalized heterocycles. Its electrophilic carbonyl center facilitates nucleophilic ring-opening reactions with amines, alcohols, and thiols under mild conditions. The compound exhibits excellent bench stability and compatibility with diverse functional groups, making it ideal for modular synthesis workflows in medicinal chemistry and materials science applications.

Synthesis

  • Route1
    • null|null
      201230-82-2
    • In-stock
      1,3-Propanediol|CS-W018490
      504-63-2
    • ~72%
    • In-stock
      1,3-Dioxan-2-one|CS-0155207
      2453-03-4

    References

    • Tetrahedron Letters, , vol. 50, # 52 p. 7330 - 7332
  • Route2
    • null|null
      124-38-9
    • null|null
      627-30-5
    • ~96%
    • In-stock
      1,3-Dioxan-2-one|CS-0155207
      2453-03-4

    References

    • Green Chemistry, , vol. 15, # 8 p. 2086 - 2090
  • Route3

    References

    • US2010/123097 A1, ; Page/Page column 8 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   35.53
  • LogP   0.5433
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

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