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CS-W001157 4
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4-Chloropyridine-2,3-diamine

  • CAS No. 24484-98-8

  • Cat. No. CS-W022164
  • Purity≥97%
  • MDL No.MFCD13181777

*For research and further manufacturing use only, not for direct human use.

4-Chloropyridine-2,3-diamine|CS-W022164

Structure of 24484-98-8

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General Information

  • CAS No. 24484-98-8
  • Cat. No. CS-W022164
  • Purity ≥97%
  • MDL No. MFCD13181777
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₆ClN₃
  • Molecular Weight 143.57
  • Synonym(s) 2,3-Diamino-4-chloropyridine
  • SMILES NC1=NC=CC(Cl)=C1N

Description

4-Chloropyridine-2,3-diamine features a pyridine core with strategically positioned amino groups and a chlorine substituent, enabling direct incorporation into heterocyclic scaffolds. This electron-deficient diamine serves as a key building block for pharmaceutical intermediates and functional materials, offering high reactivity under mild conditions.

Application

4-Chloropyridine-2,3-diamine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through palladium-catalyzed cross-coupling and nucleophilic substitution reactions. Its ortho-diamine functionality offers enhanced coordination for metal complexes and facilitates downstream derivatization, while the chloropyridine moiety provides a handle for selective functionalization. The compound exhibits good bench stability and is compatible with standard purification methods, making it well-suited for iterative synthesis campaigns in API development.

Synthesis

  • Route1

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 23 p. 6567 - 6571

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   64.93
  • LogP   0.8994
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   0

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