Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

  • CAS No. 24391-41-1

  • Cat. No. CS-0036069
  • Purity≥96%
  • MDL No.MFCD12406095

*For research and further manufacturing use only, not for direct human use.

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile|CS-0036069

Structure of 24391-41-1

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 24391-41-1
  • Cat. No. CS-0036069
  • Purity ≥96%
  • MDL No. MFCD12406095
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₃ClN₄
  • Molecular Weight 178.58
  • Synonym(s) 7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, 4-chloro-
  • SMILES C(#N)C1=CNC2=NC=NC(=C12)Cl

Description

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile is a heterocyclic building block featuring a chlorinated pyrrolopyrimidine core with a nitrile group at the C5 position. This electron-deficient scaffold integrates readily into medicinal chemistry campaigns, enabling direct functionalization for kinase inhibitors and nucleoside analogs under standard conditions.

Application

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile serves as a versatile building block for the synthesis of purine analogs and kinase inhibitor scaffolds. Its chlorine and nitrile groups enable selective functionalization via nucleophilic substitution and coupling reactions, offering high stability under standard bench conditions and facilitating purification by crystallization or chromatography.

Synthesis

  • Route1
    • null|null
      908287-23-0
    • ~95%
    • In-stock
      4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile|CS-0036069
      24391-41-1

    References

    • INFINITY PHARMACEUTICALS INC.; INTELLIKINE, LLC; CASTRO, Alfredo, C.; EVANS, Catherine, A.; JANARDANANNAIR, Somarajannair; LESCARBEAU, Andre; LIU, Tao; SNYDER, Daniel, A.; TREMBLAY, Martin, R.; REN, Pingda; LIU, Yi; LI, Liansheng; CHAN, Katrina Patent: WO2013/12915 A1, 2013 ; Location in patent: Paragraph 00942 ; WO 2013/012915 A1
  • Route2
    • In-stock
      5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine|CS-W005086
      22276-95-5
    • null|null
      19158-51-1
    • ~%
    • In-stock
      4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile|CS-0036069
      24391-41-1

    References

    • WO2012/80735 A1, ; Page/Page column 12; 44 ; WO 2012/080735 A1
  • Route3

    References

    • US6395733 B1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   65.36
  • LogP   1.48298
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 24391-41-1 sigma24391-41-1 manufacturer24391-41-1 price24391-41-1 structure24391-41-1 SDSbuy 24391-41-124391-41-1 supplier24391-41-1 uses24391-41-1 molecular weightprice of 24391-41-124391-41-1 chemical name formula of 24391-41-1
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label