4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

Name: 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 24391-41-1
Cat. No. CS-0036069
Purity≥96%
MDL No.MFCD12406095

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile|CS-0036069

Structure of 24391-41-1

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Description

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile is a heterocyclic building block featuring a chlorinated pyrrolopyrimidine core with a nitrile group at the C5 position. This electron-deficient scaffold integrates readily into medicinal chemistry campaigns, enabling direct functionalization for kinase inhibitors and nucleoside analogs under standard conditions.

Application

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile serves as a versatile building block for the synthesis of purine analogs and kinase inhibitor scaffolds. Its chlorine and nitrile groups enable selective functionalization via nucleophilic substitution and coupling reactions, offering high stability under standard bench conditions and facilitating purification by crystallization or chromatography.

General Information

CAS No. 24391-41-1
Cat. No. CS-0036069
Purity ≥96%
MDL No. MFCD12406095
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₃ClN₄
Molecular Weight 178.58
Synonym(s) 7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, 4-chloro-
SMILES C(#N)C1=CNC2=NC=NC(=C12)Cl

Computational Chemistry Data

TPSA 65.36
LogP 1.48298
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Cyanide/Nitrile

Building Blocks Skeleton Aromatic heterocycle compounds Pyrrole compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

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4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

CAS No. 24391-41-1

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