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CS-W001157 4
Total: USD 88.00

6-Chloropyridine-3,4-dicarboxylic acid

  • CAS No. 243835-70-3

  • Cat. No. CS-0102808
  • Molecule weight201.56
  • Purity≥96%
  • MDL No.MFCD03411696

*For research and further manufacturing use only, not for direct human use.

6-Chloropyridine-3,4-dicarboxylic acid|CS-0102808

Structure of 243835-70-3

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General Information

  • CAS No. 243835-70-3
  • Cat. No. CS-0102808
  • Purity ≥96%
  • MDL No. MFCD03411696
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄ClNO₄
  • Molecular Weight 201.56
  • Synonym(s) None
  • SMILES O=C(C1=C(C(O)=O)C=C(Cl)N=C1)O

Description

6-Chloropyridine-3,4-dicarboxylic acid features a pyridine core functionalized with chlorine and two carboxylic acid groups at the 6-, 3-, and 4-positions. This arrangement imparts strong electron-withdrawing character and enhances solubility in polar solvents. The molecule serves as a valuable scaffold for constructing bioactive heterocycles and metal-organic frameworks. Its stability under standard conditions supports reliable use in synthetic workflows.

Application

6-Chloropyridine-3,4-dicarboxylic acid serves as a versatile building block in heterocyclic synthesis, enabling direct functionalization at the 2-position via palladium-catalyzed cross-coupling. Its carboxylic acid groups facilitate salt formation and derivatization, while the chlorine atom provides a reliable handle for nucleophilic substitution. The molecule exhibits excellent bench stability and compatibility with standard purification techniques, making it well-suited for use in medicinal chemistry campaigns and API intermediate development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   87.49
  • LogP   1.1314
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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