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CS-W001157 4
Total: USD 88.00

5-(4-Hydroxyphenyl)imidazolidine-2,4-dione

  • CAS No. 2420-17-9

  • Cat. No. CS-W010708
  • Molecule weight192.17
  • Purity≥98%
  • MDL No.MFCD00044002

*For research and further manufacturing use only, not for direct human use.

5-(4-Hydroxyphenyl)imidazolidine-2,4-dione|CS-W010708

Structure of 2420-17-9

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General Information

  • CAS No. 2420-17-9
  • Cat. No. CS-W010708
  • Purity ≥98%
  • MDL No. MFCD00044002
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₈N₂O₃
  • Molecular Weight 192.17
  • Synonym(s) 4-Hydroxyphenyl hydantoin
  • SMILES O=C1NC(C(C2=CC=C(O)C=C2)N1)=O

Description

This imidazolidinedione scaffold integrates a para-hydroxyphenyl moiety, enhancing solubility and enabling hydrogen-bonding interactions. It serves as a stable, bioisosteric surrogate in medicinal chemistry, particularly for targeting kinase domains and modulating receptor activity under physiological conditions.

Application

5-(4-Hydroxyphenyl)imidazolidine-2,4-dione serves as a stable, bench-compatible building block for the synthesis of bioactive heterocycles. Its phenolic functionality enables direct derivatization or coupling reactions, while the imidazolidinedione core offers orthogonal reactivity for peptide and medicinal chemistry applications. The compound exhibits excellent solubility and purification ease in standard organic protocols.

Synthesis

  • Route1
    • Glyoxalic acid 50%w/w in water|CS-W019807
      298-12-4
    • null|null
      108-95-2
    • ~58%
    • In-stock
      5-(4-Hydroxyphenyl)imidazolidine-2,4-dione|CS-W010708
      2420-17-9

    References

    • Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Patent: US4230869 A1, 1980 ;
  • Route2
    • 5-Hydroxyimidazolidine-2,4-dione|CS-0349315
      29410-13-7
    • null|null
      108-95-2
    • ~63%
    • In-stock
      5-(4-Hydroxyphenyl)imidazolidine-2,4-dione|CS-W010708
      2420-17-9

    References

    • Kenegafuchi Kagaku Kogyo Kabushiki Kaisha Patent: US5110944 A1, 1992 ;
  • Route3
    • In-stock
      Hydantoin|CS-W011328
      461-72-3
    • null|null
      108-95-2
    • ~61%
    • In-stock
      5-(4-Hydroxyphenyl)imidazolidine-2,4-dione|CS-W010708
      2420-17-9

    References

    • Showa Denko K.K. Patent: US5606071 A1, 1997 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS09
Signal Word : Warning
UN#: 3077
Class : 9
Packing Group : Ⅲ
Hazard Statements : H410
Precautionary Statements : P273-P391-P501

Quality Control

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Computational Chemistry Data

  • TPSA   78.43
  • LogP   0.2727
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   1

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