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Structure of 24190-77-0
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Methyl 4-acetamido-5-chloro-2-hydroxybenzoate features a chlorinated aromatic core with complementary hydroxyl and acetamido functionalities, enabling direct incorporation into complex heterocyclic systems. The methyl ester group provides enhanced solubility and reactivity under standard coupling conditions, while the electron-withdrawing chlorine stabilizes adjacent electrophilic centers. This scaffold supports efficient derivatization in synthetic medicinal chemistry workflows.
Methyl 4-acetamido-5-chloro-2-hydroxybenzoate serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and API intermediates. Its ortho-hydroxy and acetamido functionalities facilitate directed metalation and subsequent coupling reactions, while the chloro substituent supports palladium-catalyzed cross-coupling. The methyl ester group offers convenient derivatization options, and the molecule exhibits good bench stability and ease of purification—ideal for iterative synthetic workflows in drug discovery.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: