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CS-W001157 4
Total: USD 88.00

2-Methoxy-5-(trifluoromethyl)phenylboronic acid

  • CAS No. 240139-82-6

  • Cat. No. CS-W014758
  • Purity≥96%
  • MDL No.MFCD04039222

*For research and further manufacturing use only, not for direct human use.

2-Methoxy-5-(trifluoromethyl)phenylboronic acid|CS-W014758

Structure of 240139-82-6

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General Information

  • CAS No. 240139-82-6
  • Cat. No. CS-W014758
  • Purity ≥96%
  • MDL No. MFCD04039222
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈BF₃O₃
  • Molecular Weight 219.95
  • Synonym(s) (2-Methoxy-5-Trifluoromethylphenyl)Boronic Acid
  • SMILES OB(C1=CC(C(F)(F)F)=CC=C1OC)O

Description

2-Methoxy-5-(trifluoromethyl)phenylboronic acid features a trifluoromethyl group that enhances electron-withdrawal and metabolic stability, while the methoxy substituent improves solubility and modulates reactivity. This combination enables efficient coupling in Suzuki-Miyaura reactions under standard conditions.

Application

2-Methoxy-5-(trifluoromethyl)phenylboronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl scaffolds. Its trifluoromethyl group imparts enhanced metabolic stability and lipophilicity, while the methoxy substituent provides moderate electron-donating character and improved solubility. The boronic acid moiety exhibits excellent bench stability and compatibility with a broad range of reaction conditions, facilitating straightforward purification and integration into complex molecular architectures common in medicinal chemistry and materials science.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P261-P264-P271-P280-P302+P352-P304+P340-P362-P403-P405-P501

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Computational Chemistry Data

  • TPSA   49.69
  • LogP   0.3938
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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