(2S,4S)-1-((S)-2-Amino-3,3-Dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide hydrochloride

Name: (2S,4S)-1-((S)-2-Amino-3,3-Dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide hydrochloride
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CAS No. 2380273-26-5
Cat. No. CS-0757850
Purity≥96%
MDL No.None

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(2S,4S)-1-((S)-2-Amino-3,3-Dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide hydrochloride|CS-0757850

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General Information

CAS No. 2380273-26-5
Cat. No. CS-0757850
Purity ≥96%
MDL No. None
Storage -20°C, sealed storage, away from moisture and light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₃H₃₃ClN₄O₃S
Molecular Weight 481.05
Synonym(s) None
SMILES C[C@@H](C1=CC=C(C2=C(N=CS2)C)C=C1)NC([C@@H]3C[C@@H](CN3C([C@H](C(C)(C)C)N)=O)O)=O.Cl

Description

This chiral pyrrolidine derivative features a hydroxy group at C4 and a strategically positioned amino acid moiety, enabling precise integration into peptide-based scaffolds. The (S)-configured side chain enhances target engagement, while the hydrochloride salt improves solubility and handling under standard conditions.

Application

(2S,4S)-1-((S)-2-Amino-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide hydrochloride serves as a stereochemically defined peptidomimetic building block, enabling efficient access to complex heterocyclic scaffolds. Its hydroxyl and amide functionalities support orthogonal functionalization, while the chiral pyrrolidine core provides structural rigidity for conformationally constrained libraries. Bench-stable and readily purified by recrystallization, it functions effectively in solid-phase and solution-phase peptide synthesis workflows.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 108.55
LogP 3.05272
H_Acceptors 6
H_Donors 3
Rotatable_Bonds 5

Other Classifications

Building Blocks Functional Group Alcohol

Building Blocks Functional Group Amide

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Building Blocks Skeleton Aromatic heterocycle compounds Thiazole compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

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(2S,4S)-1-((S)-2-Amino-3,3-Dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide hydrochloride

CAS No. 2380273-26-5

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