2-Methoxyphenyl dihydrouracil

Name: 2-Methoxyphenyl dihydrouracil
Brand: ChemScene
Availability: InStock
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CAS No. 2377643-33-7
Cat. No. CS-0380726
Purity≥95%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Methoxyphenyl dihydrouracil|CS-0380726

Structure of 2377643-33-7

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Description

2-Methoxyphenyl dihydrouracil features a phenolic methoxy group that enhances solubility and modulates electronic properties, enabling efficient incorporation into bioactive heterocycles. This bench-stable scaffold integrates readily into medicinal chemistry campaigns targeting nucleoside analogs and enzyme inhibitors under standard conditions.

Application

2-Methoxyphenyl dihydrouracil serves as a stable, bench-ready building block for the synthesis of uracil-based heterocycles and bioactive analogs. Its ortho-methoxyaryl substituent enhances solubility and facilitates downstream functionalization, while the dihydrouracil core enables selective transformations under mild conditions. Functions effectively in coupling reactions and serves as a versatile intermediate in medicinal chemistry campaigns requiring nitrogen-rich scaffolds.

General Information

CAS No. 2377643-33-7
Cat. No. CS-0380726
Purity ≥95%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₂H₁₂N₂O₅
Molecular Weight 264.23
Synonym(s) None
SMILES O=C(O)C1=CC=C(OC)C(N(C(N2)=O)CCC2=O)=C1

Computational Chemistry Data

TPSA 95.94
LogP 0.8397
H_Acceptors 4
H_Donors 2
Rotatable_Bonds 3

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Other Classifications

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Life Science PROTAC Ligands for E3 Ligase

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Proteolysis Targeting Chimera Research Reagents

Biochemistry Pharmaceutical Development and Drug Discovery Research Proteolysis Targeting Chimera Research Reagents

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2-Methoxyphenyl dihydrouracil

CAS No. 2377643-33-7

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