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Structure of 2374958-84-4
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This chiral bis-imidazole features two trifluoromethyl-substituted aryl groups and sterically demanding isopropyl moieties, conferring enhanced solubility and stability. The rigid, electron-deficient framework enables effective coordination in asymmetric catalysis and ligand design.
(4S,4'S)-4,4'-Diisopropyl-1,1'-bis(4-(trifluoromethyl)phenyl)-4,4',5,5'-tetrahydro-1H,1'H-2,2'-biimidazole serves as a sterically encumbered, bench-stable chiral ligand scaffold in transition-metal catalysis. Its rigid biimidazole core with ortho-substituted trifluoromethyl aryl groups enables effective coordination to palladium and nickel centers, facilitating asymmetric cross-coupling reactions. The diisopropyl substituents enhance solubility and reduce aggregation, while the tetrahydro configuration maintains conformational rigidity critical for enantioselectivity. This structure functions reliably in standard synthetic workflows requiring high stereocontrol and functional group tolerance.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319
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Precautionary Statements : P264-P280-P302+P352-P362+P364
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Lot numbers can be found on the outside label of a product: