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CS-W001157 4
Total: USD 88.00

4-Methoxybenzenecarbothioamide

  • CAS No. 2362-64-3

  • Cat. No. CS-W017831
  • Purity≥95%
  • MDL No.MFCD00040993

*For research and further manufacturing use only, not for direct human use.

4-Methoxybenzenecarbothioamide|CS-W017831

Structure of 2362-64-3

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General Information

  • CAS No. 2362-64-3
  • Cat. No. CS-W017831
  • Purity ≥95%
  • MDL No. MFCD00040993
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉NOS
  • Molecular Weight 167.23
  • Synonym(s) Thio-p-anisamide
  • SMILES COC1=CC=C(C(N)=S)C=C1

Description

4-Methoxybenzenecarbothioamide features a para-methoxy-substituted benzene ring linked to a thiourea functional group, delivering enhanced solubility and stability in polar solvents. This electron-rich arylthiourea integrates readily into synthetic scaffolds for pharmaceutical intermediates and ligand design, offering robust reactivity under standard bench conditions.

Application

4-Methoxybenzenecarbothioamide serves as a versatile building block in synthetic organic chemistry, enabling the construction of thioamide-containing heterocycles and pharmaceutical intermediates. Its methoxy-substituted aromatic ring enhances solubility and modulates reactivity, while the thiocarbonyl group participates reliably in nucleophilic additions and condensation reactions. The compound exhibits good bench stability and is readily purified by recrystallization, facilitating integration into multi-step synthesis workflows.

Synthesis

  • Route1
    • 4-Methoxybenzaldehyde, ≥ 99% GC|CS-0676496
      123-11-5
    • ~91%
    • In-stock
      4-Methoxybenzenecarbothioamide|CS-W017831
      2362-64-3

    References

    • Tetrahedron Letters, , vol. 53, # 52 p. 7113 - 7116
  • Route2

    References

    • Tetrahedron Letters, , vol. 54, # 17 p. 2164 - 2170
  • Route3

    References

    • Journal of Organic Chemistry, , vol. 76, # 6 p. 1546 - 1553

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H317
Precautionary Statements : P261-P272-P280-P302+P352-P362+P364-P501

Quality Control

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   1.3294
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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