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CS-W001157 4
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Triethyl 2-fluoro-2-phosphonoacetate

  • CAS No. 2356-16-3

  • Cat. No. CS-W012781
  • Purity≥97%
  • MDL No.MFCD00134400

*For research and further manufacturing use only, not for direct human use.

Triethyl 2-fluoro-2-phosphonoacetate|CS-W012781

Structure of 2356-16-3

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General Information

  • CAS No. 2356-16-3
  • Cat. No. CS-W012781
  • Purity ≥97%
  • MDL No. MFCD00134400
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₆FO₅P
  • Molecular Weight 242.18
  • Synonym(s) ethyl (diethoxyphosphoryl)(fluoro)acetate
  • SMILES O=C(OCC)C(F)P(OCC)(OCC)=O

Description

Triethyl 2-fluoro-2-phosphonoacetate delivers a potent phosphonate moiety flanked by a labile fluorine atom, enabling efficient C–P bond formation under mild conditions. This bench-stable reagent integrates readily into synthetic sequences requiring phosphonate incorporation, offering high functional group tolerance and compatibility with diverse reaction systems.

Synthesis

  • Route1
    • In-stock
      Ethyl 2-bromo-2-fluoroacetate|CS-0198023
      401-55-8
    • null|null
      122-52-1
    • ~91%
    • In-stock
      Triethyl 2-fluoro-2-phosphonoacetate|CS-W012781
      2356-16-3

    References

    • Kiddle, James J.; Gurley, Alison F. Phosphorus, Sulfur and Silicon and Related Elements, 2000 , vol. 160, p. 195 - 205
  • Route2

    References

    • Davis, Franklin A.; Han, Wei; Murphy, Christopher K. Journal of Organic Chemistry, 1995 , vol. 60, # 15 p. 4730 - 4737
  • Route3

    References

    • US5180737 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   61.83
  • LogP   2.1112
  • H_Acceptors   5
  • H_Donors   0
  • Rotatable_Bonds   7

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