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CS-W001157 4
Total: USD 88.00

3-Amino-2,6-piperidinedione

  • CAS No. 2353-44-8

  • Cat. No. CS-0020118
  • Purity≥95%
  • MDL No.MFCD11506223

*For research and further manufacturing use only, not for direct human use.

3-Amino-2,6-piperidinedione|CS-0020118

Structure of 2353-44-8

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General Information

  • CAS No. 2353-44-8
  • Cat. No. CS-0020118
  • Purity ≥95%
  • MDL No. MFCD11506223
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₈N₂O₂
  • Molecular Weight 128.13
  • Synonym(s) None
  • SMILES O=C(C(N)CC1)NC1=O

Description

3-Amino-2,6-piperidinedione features a fused bicyclic core with strategically positioned amino and carbonyl groups, enabling direct integration into peptide mimetics and heterocyclic scaffolds. This bench-stable derivative exhibits enhanced solubility in polar solvents and serves as a key intermediate for bioactive compound synthesis.

Application

3-Amino-2,6-piperidinedione serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted piperidine scaffolds. Its amine and diketone functionalities support diverse transformations, including reductive amination, nucleophilic substitution, and cyclization reactions. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis campaigns in API development.

Synthesis

  • Route1

    References

    • EP1964842 A1, ; Page/Page column 28 ;
  • Route2

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 2 p. 421 - 425
  • Route3

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 2 p. 421 - 425

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3259
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

  • TPSA   72.19
  • LogP   -1.2497
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   0

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