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Structure of 23432-43-1
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6-Chloroquinolin-4-ol delivers a rigid, electron-deficient quinoline scaffold bearing a strategically positioned hydroxyl group. This combination enables direct functionalization at the 4-position while maintaining structural integrity under standard reaction conditions. The chlorine substituent enhances electrophilicity for downstream coupling reactions and contributes to improved metabolic stability in bioactive molecule design.
6-Chloroquinolin-4-ol serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C-4 hydroxyl and C-6 chlorine positions. Its stability under standard reaction conditions facilitates nucleophilic substitution, palladium-catalyzed coupling, and derivatization for quinoline-based pharmacophores. The compound exhibits favorable solubility and ease of purification, supporting its use in iterative synthesis of kinase inhibitors and other bioactive heterocycles.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: