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CS-W001157 4
Total: USD 88.00

Propargyl-Tos

  • CAS No. 23418-85-1

  • Cat. No. CS-0012100
  • Purity≥95%
  • MDL No.MFCD00041687

*For research and further manufacturing use only, not for direct human use.

Propargyl-Tos|CS-0012100

Structure of 23418-85-1

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General Information

  • CAS No. 23418-85-1
  • Cat. No. CS-0012100
  • Purity ≥95%
  • MDL No. MFCD00041687
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₂O₃S
  • Molecular Weight 224.28
  • Synonym(s) None
  • SMILES C#CCCOS(C1=CC=C(C)C=C1)(=O)=O

Description

Propargyl-Tos features a terminal alkyne group conjugated to a para-toluenesulfonyl (Tos) directing group, enabling selective functionalization in cross-coupling and click chemistry applications. This bench-stable reagent integrates readily into complex molecular architectures under mild conditions.

Synthesis

  • Route1
    • null|null
      98-59-9
    • In-stock
      3-Butyn-1-ol|CS-W001947
      927-74-2
    • ~99%
    • In-stock
      Propargyl-Tos|CS-0012100
      23418-85-1

    References

    • Fujiwara, Kenshu; Suzuki, Yuki; Koseki, Nao; Murata, Shun-Ichi; Murai, Akio; Kawai, Hidetoshi; Suzuki, Takanori Tetrahedron Letters, 2011 , vol. 52, # 43 p. 5589 - 5592
  • Route2
    • null|null
      121-44-8
    • null|null
      98-59-9
    • In-stock
      3-Butyn-1-ol|CS-W001947
      927-74-2
    • ~94%
    • In-stock
      Propargyl-Tos|CS-0012100
      23418-85-1
    • null|null
      554-68-7

    References

    • RIB-X PHARMACEUTICALS, INC. Patent: WO2004/29066 A2, 2004 ; Location in patent: Page/Page column 215 ;
  • Route3

    References

    • Zammit, Steven C.; Cox, Alison J.; Gow, Renae M.; Zhang, Yuan; Gilbert, Richard E.; Krum, Henry; Kelly, Darren J.; Williams, Spencer J. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 24 p. 7003 - 7006

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   43.37
  • LogP   1.72362
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   4

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