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CS-W001157 4
Total: USD 88.00

5-Fluorocytidine

  • CAS No. 2341-22-2

  • Cat. No. CS-0097785
  • Purity≥97%
  • MDL No.MFCD00210953

*For research and further manufacturing use only, not for direct human use.

5-Fluorocytidine|CS-0097785

Structure of 2341-22-2

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General Information

  • CAS No. 2341-22-2
  • Cat. No. CS-0097785
  • Purity ≥97%
  • MDL No. MFCD00210953
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₂FN₃O₅
  • Molecular Weight 261.21
  • Synonym(s) None
  • SMILES OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(N=C(N)C(F)=C2)=O)O1

Description

5-Fluorocytidine integrates a fluorine atom at the 5-position of cytidine, enhancing its metabolic stability and enabling targeted incorporation into RNA. This modified nucleoside serves as a potent probe for studying RNA dynamics and is particularly valuable in antiviral research and nucleic acid labeling workflows.

Application

5-Fluorocytidine serves as a nucleoside building block for the synthesis of fluorinated oligonucleotides and antiviral agents. Its fluorine substitution enhances metabolic stability and modulates base-pairing properties, enabling use in RNA-directed therapeutics. The compound exhibits bench stability and compatibility with standard phosphoramidite coupling protocols, facilitating efficient incorporation into synthetic oligonucleotide sequences.

Synthesis

  • Route1
    • null|null
      53294-73-8
    • ~91%
    • In-stock
      5-Fluorocytidine|CS-0097785
      2341-22-2

    References

    • Ghosh, Avik K.; Schuster, Gary B. Journal of the American Chemical Society, 2006 , vol. 128, # 13 p. 4172 - 4173
  • Route2
    • null|null
      2560-60-3
    • ~%
    • In-stock
      5-Fluorocytidine|CS-0097785
      2341-22-2

    References

    • Journal of the American Chemical Society, , vol. 122, # 42 p. 10259 - 10267
  • Route3
    • null|null
      669055-50-9
    • ~48%
    • In-stock
      5-Fluorocytidine|CS-0097785
      2341-22-2

    References

    • Takatsuki, Ken-Ichi; Ohgushi, Sumito; Kohmoto, Shigeo; Kishikawa, Keiki; Yamamoto, Makoto Nucleosides, Nucleotides and Nucleic Acids, 2006 , vol. 25, # 7 p. 719 - 734

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   130.83
  • LogP   -2.4239
  • H_Acceptors   8
  • H_Donors   4
  • Rotatable_Bonds   2

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