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Tetrahydro-2H-thiopyran-4-amine hydrochloride

  • CAS No. 233763-40-1

  • Cat. No. CS-0043960
  • Purity≥95%
  • MDL No.MFCD09701226

*For research and further manufacturing use only, not for direct human use.

Tetrahydro-2H-thiopyran-4-amine hydrochloride|CS-0043960

Structure of 233763-40-1

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General Information

  • CAS No. 233763-40-1
  • Cat. No. CS-0043960
  • Purity ≥95%
  • MDL No. MFCD09701226
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₂ClNS
  • Molecular Weight 153.67
  • Synonym(s) thian-4-amine hydrochloride
  • SMILES NC1CCSCC1.[H]Cl

Description

Tetrahydro-2H-thiopyran-4-amine hydrochloride offers a stable, moisture-tolerant amine handle ideal for conjugation and synthesis. The thiopyran ring provides enhanced rigidity and solubility in polar media, while the protonated amine ensures excellent reactivity under standard conditions. This derivative serves as a key scaffold in medicinal chemistry and peptide coupling applications.

Application

Tetrahydro-2H-thiopyran-4-amine hydrochloride serves as a versatile sulfur-containing heterocyclic building block, enabling efficient access to bioactive scaffolds. Its amine functionality facilitates straightforward derivatization and salt formation, enhancing solubility and handling. The molecule exhibits bench stability and compatibility with standard synthetic protocols, making it ideal for medicinal chemistry campaigns requiring nitrogen- and sulfur-donor motifs in drug discovery and process development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   1.2625
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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