Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

3-Chloro-4-hydroxybenzonitrile

  • CAS No. 2315-81-3

  • Cat. No. CS-D0375
  • Purity≥97%
  • MDL No.MFCD01567246

*For research and further manufacturing use only, not for direct human use.

3-Chloro-4-hydroxybenzonitrile|CS-D0375

Structure of 2315-81-3

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 2315-81-3
  • Cat. No. CS-D0375
  • Purity ≥97%
  • MDL No. MFCD01567246
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄ClNO
  • Molecular Weight 153.57
  • Synonym(s) 4-Cyano-2-chlorophenol; 3-Chloro-4-hydroxybenzonitrile
  • SMILES N#CC1=CC=C(O)C(Cl)=C1

Description

3-Chloro-4-hydroxybenzonitrile features a hydroxyl group flanked by chlorine and nitrile substituents on a benzene ring, enabling selective functionalization in pharmaceutical intermediates. This electron-deficient scaffold supports efficient coupling reactions under mild conditions and exhibits enhanced solubility in polar aprotic solvents compared to analogs lacking the hydroxyl moiety.

Application

3-Chloro-4-hydroxybenzonitrile serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the phenolic hydroxyl and ortho-chlorine positions. Its nitrile group facilitates downstream transformations such as amide formation or reduction to primary amines, while the hydroxyl group supports etherification or esterification. The molecule exhibits good bench stability and compatibility with standard coupling reactions, making it well-suited for constructing complex heterocyclic scaffolds and API intermediates.

Synthesis

  • Route1
    • 4-(Benzyloxy)-3-chlorobenzonitrile|CS-B1030
      142247-74-3
    • ~86%
    • In-stock
      3-Chloro-4-hydroxybenzonitrile|CS-D0375
      2315-81-3

    References

    • Dawson, Marcia I.; Xia, Zebin; Liu, Gang; Fontana, Joseph A.; Farhana, Lulu; Patel, Bhamik B.; Arumugarajah, Sankari; Bhuiyan, Mohammad; Zhang, Xiao-Kun; Han, Young-Hoon; Stallcup, William B.; Fukushi, Jun-Ichi; Mustelin, Tomas; Tautz, Lutz; Su, Ying; Harris, Danni L.; Waleh, Nahid; Hobbs, Peter D.; Jong, Ling; Chao, Wan-Ru; Schiff, Leonard J.; Sani, Brahma P. Journal of Medicinal Chemistry, 2007 , vol. 50, # 11 p. 2622 - 2639
  • Route2
    • null|null
      1428636-98-9
    • ~95%
    • In-stock
      3-Chloro-4-hydroxybenzonitrile|CS-D0375
      2315-81-3

    References

    • Chinnagolla, Ravi Kiran; Pimparkar, Sandeep; Jeganmohan, Masilamani Chemical Communications, 2013 , vol. 49, # 30 p. 3146 - 3148
  • Route3
    • null|null
      431998-28-6
    • ~%
    • In-stock
      3-Chloro-4-hydroxybenzonitrile|CS-D0375
      2315-81-3

    References

    • Journal of Medicinal Chemistry, , vol. 50, # 11 p. 2622 - 2639

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   44.02
  • LogP   1.91728
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 3-Chloro-4-hydroxybenzonitrile sigma3-Chloro-4-hydroxybenzonitrile manufacturer3-Chloro-4-hydroxybenzonitrile price3-Chloro-4-hydroxybenzonitrile structure3-Chloro-4-hydroxybenzonitrile SDSbuy 3-Chloro-4-hydroxybenzonitrile3-Chloro-4-hydroxybenzonitrile supplier3-Chloro-4-hydroxybenzonitrile uses3-Chloro-4-hydroxybenzonitrile molecular weightprice of 3-Chloro-4-hydroxybenzonitrile3-Chloro-4-hydroxybenzonitrile chemical name formula of 3-Chloro-4-hydroxybenzonitrile
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label