1-Propyl-4-piperidone

Name: 1-Propyl-4-piperidone
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 23133-37-1
Cat. No. CS-W018299
Purity≥98%
MDL No.MFCD00010433

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 23133-37-1

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General Information

CAS No. 23133-37-1
Cat. No. CS-W018299
Purity ≥98%
MDL No. MFCD00010433
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₁₅NO
Molecular Weight 141.21
Synonym(s) 4-oxo-1-propylpiperidinium; 1-Propyl-4-piperidone
SMILES O=C1CCN(CCC)CC1

Description

1-Propyl-4-piperidone is a cyclic ketone featuring a saturated piperidine ring with a propyl substituent at the nitrogen and a carbonyl group at the C4 position. This configuration imparts enhanced lipophilicity and metabolic stability, making it a valuable intermediate in the synthesis of pharmaceuticals, particularly those targeting CNS disorders. The compound exhibits favorable reactivity in amine functionalization and coupling reactions under standard conditions.

Application

1-Propyl-4-piperidone serves as a versatile scaffold in medicinal chemistry, enabling the construction of bioactive heterocycles through standard functionalization at the nitrogen and carbonyl positions. Its bench-stable nature and compatibility with common coupling and reduction protocols facilitate efficient synthesis of piperidine-based intermediates for pharmaceutical development.

Synthesis

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- 106-94-5
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  23133-37-1
References
- Bioorganic and Medicinal Chemistry, , vol. 12, # 9 p. 2115 - 2137
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- 106-94-5
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  23133-37-1
References
- Bioorganic and Medicinal Chemistry, , vol. 15, # 2 p. 1022 - 1033

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 20.31
LogP 1.0613
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 2

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Key Words

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1-Propyl-4-piperidone

CAS No. 23133-37-1

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