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CS-W001157 4
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Quinoxaline-6-carbonitrile

  • CAS No. 23088-24-6

  • Cat. No. CS-0044491
  • Purity≥97%
  • MDL No.MFCD08669502

*For research and further manufacturing use only, not for direct human use.

Quinoxaline-6-carbonitrile|CS-0044491

Structure of 23088-24-6

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General Information

  • CAS No. 23088-24-6
  • Cat. No. CS-0044491
  • Purity ≥97%
  • MDL No. MFCD08669502
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₅N₃
  • Molecular Weight 155.16
  • Synonym(s) 6-QUINOXALINECARBONITRILE
  • SMILES N#CC1=CC=C2N=CC=NC2=C1

Description

Quinoxaline-6-carbonitrile delivers a rigid, electron-deficient heteroaromatic core ideal for constructing functional materials and bioactive scaffolds. The nitrile group enables direct coupling reactions and enhances molecular polarity, while the fused ring system supports π-stacking interactions in supramolecular systems.

Application

Quinoxaline-6-carbonitrile serves as a versatile heterocyclic building block in medicinal chemistry and materials science, enabling efficient access to functionalized quinoxaline scaffolds. Its nitrile group supports diverse transformations including hydrolysis, nucleophilic addition, and coupling reactions, while the rigid aromatic core enhances metabolic stability. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for high-throughput synthesis and process-scale applications.

Synthesis

  • Route1

    References

    • Climent; Corma; Hernandez; Hungria; Iborra; Martinez-Silvestre Journal of Catalysis, 2012 , vol. 292, p. 118 - 129
  • Route2

    References

    • Nasielski, J.; Heilporn, S.; Nasielski-Hinkens, R.; Tinant, B.; Declercq, J. P. Tetrahedron, 1989 , vol. 45, # 24 p. 7795 - 7804
  • Route3
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      6935-29-1
    • ~%
    • In-stock
      Quinoxaline-6-carbonitrile|CS-0044491
      23088-24-6

    References

    • Nasielski, J.; Heilporn, S.; Nasielski-Hinkens, R.; Tinant, B.; Declercq, J. P. Tetrahedron, 1989 , vol. 45, # 24 p. 7795 - 7804

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   49.57
  • LogP   1.50148
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

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