(S)-1,3-Dihydrospiro[indene-2,4'-piperidin]-1-amine dihydrochloride

Name: (S)-1,3-Dihydrospiro[indene-2,4'-piperidin]-1-amine dihydrochloride
Brand: ChemScene
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CAS No. 2306254-23-7
Cat. No. CS-0136130
Purity≥98%
MDL No.MFCD32068285

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(S)-1,3-Dihydrospiro[indene-2,4'-piperidin]-1-amine dihydrochloride|CS-0136130

Structure of 2306254-23-7

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General Information

CAS No. 2306254-23-7
Cat. No. CS-0136130
Purity ≥98%
MDL No. MFCD32068285
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₃H₂₀Cl₂N₂
Molecular Weight 275.22
Synonym(s) None
SMILES N[C@H]1C2(CCNCC2)CC3=CC=CC=C31.Cl.Cl

Description

(S)-1,3-Dihydrospiro[indene-2,4'-piperidin]-1-amine dihydrochloride features a rigid spirocyclic scaffold with a stereodefined piperidine nitrogen, delivering enhanced conformational control. The protonated amine enhances solubility and facilitates salt formation, improving handling and stability in aqueous media. This configuration supports efficient incorporation into bioactive scaffolds for medicinal chemistry applications.

Application

(S)-1,3-Dihydrospiro[indene-2,4'-piperidin]-1-amine dihydrochloride serves as a stereochemically defined spirocyclic scaffold for medicinal chemistry exploration. The piperidine nitrogen enables straightforward functionalization, while the indene moiety provides rigidity and π-stacking potential. Bench-stable and readily purified by standard chromatography or recrystallization, it functions effectively in amine coupling reactions and facilitates the construction of complex heterocyclic architectures relevant to CNS-targeted drug discovery.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

TPSA 38.05
LogP 2.4559
H_Acceptors 2
H_Donors 2
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Spirol Rings compounds

Drug Discovery Cancer SHP2

Key Words

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(S)-1,3-Dihydrospiro[indene-2,4'-piperidin]-1-amine dihydrochloride

CAS No. 2306254-23-7

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