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CS-W001157 4
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Oxazole-4-carboxamide

  • CAS No. 23012-15-9

  • Cat. No. CS-W003785
  • Purity≥98%
  • MDL No.MFCD11506176

*For research and further manufacturing use only, not for direct human use.

Oxazole-4-carboxamide|CS-W003785

Structure of 23012-15-9

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General Information

  • CAS No. 23012-15-9
  • Cat. No. CS-W003785
  • Purity ≥98%
  • MDL No. MFCD11506176
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₄N₂O₂
  • Molecular Weight 112.09
  • Synonym(s) Oxazole-4-carboxylic acid amide
  • SMILES NC(=O)c1cocn1

Description

Oxazole-4-carboxamide is a heterocyclic amide featuring a stable oxazole ring fused to a carboxamide group. This scaffold imparts excellent solubility in polar solvents and enhanced metabolic stability, making it a valuable building block in medicinal chemistry. The electron-deficient nature of the oxazole ring facilitates directed functionalization at the 5-position, enabling efficient coupling reactions in complex molecule synthesis.

Application

Oxazole-4-carboxamide serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to bioactive scaffolds. Its amide functionality provides enhanced solubility and hydrogen-bonding capacity, while the oxazole ring offers metabolic stability and favorable pharmacokinetic properties. The compound reacts predictably in standard coupling and functionalization protocols, facilitating rapid diversification for drug discovery applications.

Synthesis

  • Route1

    References

    • Caspi, Daniel D.; Zhang, Haiming; Virgil, Scott C.; Piller, Fabian M.; Stoltz, Brian M. Heterocycles, 2012 , vol. 86, # 2 p. 1003 - 1008

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   69.12
  • LogP   -0.2265
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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