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CS-W001157 4
Total: USD 88.00

MAC glucuronide linker-2

  • CAS No. 229977-57-5

  • Cat. No. CS-0105172
  • Purity≥97%
  • MDL No.MFCD31715406

*For research and further manufacturing use only, not for direct human use.

MAC glucuronide linker-2|CS-0105172

Structure of 229977-57-5

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General Information

  • CAS No. 229977-57-5
  • Cat. No. CS-0105172
  • Purity ≥97%
  • MDL No. MFCD31715406
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₀H₂₅NO₁₁
  • Molecular Weight 455.41
  • Synonym(s) None
  • SMILES O=C(OC)[C@@H](O1)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC2=CC=C(CO)C=C2N

Description

MAC glucuronide linker-2 enables site-specific conjugation in antibody-drug conjugates, featuring a stable, hydrolytically cleavable bond that releases payload under physiological conditions. This linker integrates seamlessly into bioconjugation workflows, offering predictable pharmacokinetics and enhanced tumor targeting through controlled drug release.

Application

MAC glucuronide linker-2 serves as a robust, hydrolytically stable conjugation handle for antibody-drug conjugate (ADC) development. It enables site-specific attachment of payload molecules via amine-reactive ester functionality, offering improved plasma stability and controlled release in target cells. The linker’s glucuronide moiety facilitates enzymatic cleavage by β-glucuronidase in the lysosomal environment, enhancing tumor-selective drug activation. Its compatibility with standard purification methods and predictable pharmacokinetic behavior make it well-suited for scalable ADC synthesis.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H315-H319-H332-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   169.91
  • LogP   -0.1671
  • H_Acceptors   12
  • H_Donors   2
  • Rotatable_Bonds   7

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